Complement C4 Is Protective for Lupus

Disease Independent of C3 Complement C4 Is Protective for Lupus

A review on the latest clinical and laboratory criteria for clinical diagnosis of Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with various organs involvement which early diagnosis of disease is critical for successful treatment. The subjects with the possibility of SLE who visit by physician, their full medical history and specific immunological tests should investigate precisely in order to subsequently asses their hematological and renal parameters t...

Complement levels and risk of organ involvement in patients with systemic lupus erythematosus

Objective Complement plays a major role in SLE. Complement participation has been linked to disease activity and damage. Our objective was to estimate the association of complement behaviour with clinical manifestations, visceral injury and mortality in patients with SLE. Methods Complement determinations (C3 and C4 levels) were analysed in patients with SLE (fulfilling American College of Rh...

Complement in lupus nephritis: the good, the bad, and the unknown.

The complement system consists of 3 pathways and more than 30 proteins, including those with biological activity that directly or indirectly mediate the effects of this system, plus a set of regulatory proteins necessary to prevent injudicious complement activation on host tissue. The role for complement in the pathogenesis of systemic lupus erythematosus (SLE) is paradoxic. On one hand, the co...

Correlation of the activation of the fourth component of complement (C4) with disease activity in systemic lupus erythematosus.

Levels of C4d, a fragment of C4 generated during activation of the classical complement pathway, were measured in the plasma of 48 patients with systemic lupus erythematosus, 11 with inactive (group 1), 23 with mildly active (group 2), 14 with moderately/severely active disease (group 3), and 30 healthy subjects. Levels of C3d, C4, and C3 were also measured and the C4d/C4 and C3d/C3 ratios calc...